No. | Schiff base | Solventa) (method)b) | Yield of Ala (Lac)c) (%) | S (e.e. %) |
1 | 8a | MeOH (A) | 50 (23) | 64 |
2 | MeOH (B) | 82 | 58 | |
3 | EtOH (A) | 58 (26) | 59 | |
4 | EtOH (B) | 58 | 53 | |
5 | 2-PrOH (A) | 34 (40) | 55 | |
6 | 2-PrOH (B) | 57 | 55 | |
7 | 2-Me-1-PrOH (B) | 20 | 67 | |
8 | THF (A) | 38 (40) | 47 | |
9 | AcOEt (A) | 45 (22) | 52 | |
10 | AcOEt (B) | 25 | 44 | |
11 | 8b | MeOH (A) | 58 (25) | 63 |
12 | MeOH (B) | 65 | 62 | |
13 | EtOH (A) | 55 (26) | 66 | |
14 | EtOH (B) | 67 | 60 | |
15 | 2-PrOH (A) | 60 (25) | 48 | |
16 | 2-PrOH (B) | 70 | 58 | |
17 | 2-Me-2-PrOH (B) | 67 | 69 | |
18 | THF (A) | 59 (20) | 45 | |
19 | AcOEt (A) | 62 (27) | 52 | |
20 | 8c | MeOH (A) | 49 (40) | 65 |
21 | MeOH (B) | 48 | 55 | |
22 | EtOH (A) | 38 (33) | 63 | |
23 | EtOH (B) | 46 | 55 | |
24 | 2-PrOH (A) | 27 (28) | 58 | |
25 | 2-PrOH (B) | 50 | 53 | |
26 | 2-Me-2-PrOH (B) | 50 | 49 | |
27 | THF (A) | 23 (20) | 47 | |
28 | AcOEt (A) | 28 (22) | 55 | |
29 | AcOEt (B) | 34 | 51 | |
30 | 8d | MeOH (B) | 30 | 62 |
31 | EtOH (B) | 17 | 63 | |
32 | 8e | MeOH (A) | 20 (17) | 55 |
33 | EtOH (A) | 18 (21) | 51 | |
34 | 2-PrOH (A) | 22 (17) | 20 | |
35 | THF (A) | 16 (10) | 23 | |
36 | AcOEt (A) | 19 (15) | 28 |